Publications
all Publications
Sonntag, T., Moresco, J.J., Yates, J.R., Montminy, M. The KLDpT activation loop motif is critical for MARK kinase activity. (2019) PLOS One. 14(12):e0225727. DOI: 10.1371/journal.pone.0225727
Rodón, L., Svensson, R.U., Wiater, E., Chun, M.G.H., Tsai, W.W., Eichner, L.J., Shaw, R.J., Montminy, M. The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer. (2019) Science Advances. 5(7):eaaw6455. DOI: 10.1126/sciadv.aaw6455
Yoon, Y.S., Tsai, W.W., Van de Velde, S., Chen, Z., Lee, K.F., Morgan, D.A., Rahmouni, K., Matsumura, S., Wiater, E., Song, Y., Montminy, M. cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1805257115
Shen, R., Wang, B., Giribaldi, M.G., Ayres, J., Thomas, J.B., Montminy, M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(23):E3307-14. DOI: 10.1073/pnas.1606106113
Hernandez, J.B., Chang, C., LeBlanc, M., Grimm, D., Le Lay, J., Kaestner, K.H., Zheng, Y., Montminy, M. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. (2015) Nature Communications. 6:7216. DOI: 10.1038/ncomms8216
Luan, B., Goodarzi, M.O., Phillips, N.G., Guo, X., Chen, Y.D., Yao, J., Allison, M., Rotter, J.I., Shaw, R., Montminy, M. Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. (2014) Cell Metabolism. 19(6):1058-65. DOI: 10.1016/j.cmet.2014.03.024
Montminy, M., Lee, K.F., Rivier, J.E., Rivier, C., Reichlin, S. Wylie Vale: neuroendocrine master. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(10):3604-5. DOI: 10.1073/pnas.1201696109
Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P.D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M., Shaw, R.J. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. (2011) Cell. 145(4):607-21. DOI: 10.1016/j.cell.2011.03.043
Wang, B., Moya, N., Niessen, S., Hoover, H., Mihaylova, M.M., Shaw, R.J., Yates, J.R., Fischer, W.H., Thomas, J.B., Montminy, M. A hormone-dependent module regulating energy balance. (2011) Cell. 145(4):596-606. DOI: 10.1016/j.cell.2011.04.013
Mair, W., Morantte, I., Rodrigues, A.P., Manning, G., Montminy, M., Shaw, R.J., Dillin, A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. (2011) Nature. 470(7334):404-8. DOI: 10.1038/nature09706
Yoon, Y.S., Lee, M.W., Ryu, D., Kim, J.H., Ma, H., Seo, W.Y., Kim, Y.N., Kim, S.S., Lee, C.H., Hunter, T., Choi, C.S., Montminy, M.R., Koo, S.H. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(41):17704-9. DOI: 10.1073/pnas.1012665107
Wang, B., Goode, J., Best, J., Meltzer, J., Schilman, P.E., Chen, J., Garza, D., Thomas, J.B., Montminy, M. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. (2008) Cell Metabolism. 7(5):434-44. DOI: 10.1016/j.cmet.2008.02.010
Qi, L., Heredia, J.E., Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., Macleod, I.X., Liew, C.W., Kulkarni, R.N., Bain, J., Newgard, C., Nelson, M., Evans, R.M., Yates, J., Montminy, M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. (2006) Science. 312(5781):1763-6. DOI: 10.1126/science.1123374
Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., Depinho, R.A., Montminy, M., Cantley, L.C. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. (2005) Science. 310(5754):1642-6. DOI: 10.1126/science.1120781
Zhang, X., Odom, D.T., Koo, S.H., Conkright, M.D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., Kadam, S., Ecker, J.R., Emerson, B., Hogenesch, J.B., Unterman, T., Young, R.A., Montminy, M. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(12):4459-64. DOI: 10.1073/pnas.0501076102
Koo, S.H., Satoh, H., Herzig, S., Lee, C.H., Hedrick, S., Kulkarni, R., Evans, R.M., Olefsky, J., Montminy, M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. (2004) Nature Medicine. 10(5):530-4. DOI: 10.1038/nm1044
Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T., Montminy, M. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. (2002) Molecular and Cellular Biology. 22(9):2974-83.
Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B.M., Montminy, M., Evans, R.M. A transcriptional switch mediated by cofactor methylation. (2001) Science. 294(5551):2507-11. DOI: 10.1126/science.1065961
Asahara, H., Dutta, S., Kao, H.Y., Evans, R.M., Montminy, M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. (1999) Molecular and Cellular Biology. 19(12):8219-25.
Mayall, T.P., Sheridan, P.L., Montminy, M.R., Jones, K.A. Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro. (1997) Genes & Development. 11(7):887-99.
Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M., Evans, R.M. Role of CBP/P300 in nuclear receptor signalling. (1996) Nature. 383(6595):99-103. DOI: 10.1038/383099a0
Nakajima, T., Fukamizu, A., Takahashi, J., Gage, F.H., Fisher, T., Blenis, J., Montminy, M.R. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. (1996) Cell. 86(3):465-74.
Parker, D., Ferreri, K., Nakajima, T., LaMorte, V.J., Evans, R.M., Koerber, S.C., Hoeger, C., Montminy, M.R. Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. (1996) Molecular and Cellular Biology. 16(2):694-703.